{"id":11130,"date":"2018-09-12T14:55:51","date_gmt":"2018-09-12T19:55:51","guid":{"rendered":"https:\/\/last-drum.flywheelsites.com\/?p=11130"},"modified":"2025-10-17T15:32:32","modified_gmt":"2025-10-17T20:32:32","slug":"ehlers-danlos-syndrome-and-other-hypermobility-spectrum-disorders-in-families-with-autism","status":"publish","type":"post","link":"https:\/\/autism.org\/ehlers-danlos-syndrome-and-other-hypermobility-spectrum-disorders-in-families-with-autism\/","title":{"rendered":"Ehlers-Danlos Syndrome and Other Hypermobility Spectrum Disorders in Families with Autism"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_6 1_6 fusion-one-sixth fusion-column-first\" style=\"--awb-bg-size:cover;width:16.666666666667%;width:calc(16.666666666667% - ( ( 4% + 4% ) * 0.16666666666667 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_2_3 2_3 fusion-two-third\" style=\"--awb-padding-top:80px;--awb-bg-size:cover;width:66.666666666667%;width:calc(66.666666666667% - ( ( 4% + 4% ) * 0.66666666666667 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-text-transform:none;\"><p><span style=\"font-weight: 400;\">Dr. Casanova dives into Ehlers-Danlos (EDS) and related hypermobility syndromes in this webinar. She describes EDS with a focus on the joint hypermobility spectrum. The presenter highlights that this field of study is in its infancy and that much more research is needed. She outlines recent findings that have shed light on the roles collagen fibers play within the body and the brain. Casanova discusses the co-occurrence of EDS and autism and other hypermobility syndrome disorders and wonders what other roles collagens play in the body. She outlines future research aims and closes with a question-and-answer session.<\/span><\/p>\n<p>Take the knowledge quiz for this presentation <strong><a href=\"#jump\">here<\/a><br \/>\n<\/strong>Learn more about Dr. Casanova <a href=\"#jump\"><strong>here<\/strong><\/a><\/p>\n<\/div><div class=\"fusion-video fusion-youtube fusion-aligncenter\" style=\"--awb-max-width:1000px;--awb-max-height:563px;--awb-width:100%;\"><div class=\"video-shortcode\"><div class=\"fluid-width-video-wrapper\" style=\"padding-top:56.3%;\" ><iframe title=\"YouTube video player 1\" src=\"https:\/\/www.youtube.com\/embed\/1A6Xd67ZBB8?wmode=transparent&autoplay=0&amp;rel=0\" width=\"1000\" height=\"563\" allowfullscreen allow=\"autoplay; fullscreen\"><\/iframe><\/div><\/div><\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-text-transform:none;\"><h3><strong>In this presentation:<br \/>\n<\/strong><\/h3>\n<p><b>2:20 &#8211; <\/b><span style=\"font-weight: 400;\">What are Ehlers-Danlos Syndromes (EDS)<br \/>\n<\/span><b>3:42 &#8211; <\/b><span style=\"font-weight: 400;\">Types and prevalence of EDS<br \/>\n<\/span><b>5:34 &#8211; <\/b><span style=\"font-weight: 400;\">Joint hypermobility spectrum<br \/>\n<\/span><b>7:18 &#8211; <\/b><span style=\"font-weight: 400;\">hEDS and HSD<br \/>\n<\/span><b>8:32 &#8211; <\/b><span style=\"font-weight: 400;\">Fibrillar collagens<br \/>\n<\/span><b>9:48 &#8211; <\/b><span style=\"font-weight: 400;\">Collagen fibers in EDS skin<br \/>\n<\/span><b>11:58 &#8211; <\/b><span style=\"font-weight: 400;\">Study:<\/span> <span style=\"font-weight: 400;\">Ultrastructural differences in collagen in \u201cunaffected\u201d family members<br \/>\n<\/span><b>13:07 &#8211; <\/b><span style=\"font-weight: 400;\">EDS and Autism<br \/>\n<\/span><b>14:32 &#8211; <\/b><span style=\"font-weight: 400;\">Study: Hereditary relationships between EDS and autism<br \/>\n<\/span><b>17:39 &#8211; <\/b><span style=\"font-weight: 400;\">EDS, autism, and the maternal immune system<br \/>\n<\/span><b>18:52 &#8211; <\/b><span style=\"font-weight: 400;\">Study: Immune symptoms in EDS<br \/>\n<\/span><b>22:20 &#8211; <\/b><span style=\"font-weight: 400;\">Mast Cell Activation Syndrome (MCAS)<br \/>\n<\/span><b>24:18 &#8211; <\/b><span style=\"font-weight: 400;\">Marfan Syndrome and TGF-beta proteins<br \/>\n<\/span><b>26:15 &#8211; <\/b><span style=\"font-weight: 400;\">Loeys-Dietz Syndrome<br \/>\n<\/span><b>26:30 &#8211; <\/b><span style=\"font-weight: 400;\">Non-fibril collagen as antibacterial agents<br \/>\n<\/span><b>29:16 &#8211; <\/b><span style=\"font-weight: 400;\">Hormonal and autonomic symptoms in EDS and autism<br \/>\n<\/span><b>31:25 &#8211; <\/b><span style=\"font-weight: 400;\">Postural Orthostatic Tachycardia Syndrome (POTS) and treatments<br \/>\n<\/span><b>37:03 &#8211; <\/b>Connective tissue in the brain<br \/>\n<b>44:35 &#8211; <\/b><span style=\"font-weight: 400;\">Future research avenues<br \/>\n<\/span><b>47:30 &#8211; <\/b><span style=\"font-weight: 400;\">Question and answer session<\/span><\/p>\n<\/div><div class=\"fusion-text fusion-text-3\" style=\"--awb-text-transform:none;\"><h3><strong>Summary: <\/strong><\/h3>\n<p><span style=\"font-weight: 400;\">Dr. Casanova defines Ehlers-Danlos Syndromes as a group of rare diseases characterized by issues with joint hypermobility, skin elasticity, tissue fragility, and musculoskeletal pain and instability <\/span><b>(2:20)<\/b><span style=\"font-weight: 400;\">. The prevalence rate of EDS is one to ten in every 5,000 people. However, the presenter notes that prevalence is likely higher in specific clinical populations <\/span><b>(4:44)<\/b><span style=\"font-weight: 400;\">. Casanova remarks throughout the presentation that collagen research is in its infancy, and more clinical trials are needed.\u00a0<\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: 400;\">The most common type of EDS is Hypermobile EDS (hEDS), which is associated with collagen mutations <\/span><b>(3:41)<\/b><span style=\"font-weight: 400;\">. Casanova outlines the joint hypermobility spectrum noting variation in degrees (localized or generalized) of hypermobility and levels of impairment &#8211; ranging from asymptomatic to severe musculoskeletal impairment <\/span><b>(5:34)<\/b><span style=\"font-weight: 400;\">. She explains the importance of fibril collagen fibers in creating major structural components of connective tissues <\/span><b>(9:30)<\/b><span style=\"font-weight: 400;\"> and notes observed variability in size, density, and shape of fibril collagen across types and cases of EDS <\/span><b>(9:48)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: 400;\">The prevalence of co-occurrence between the joint hypermobility and autism spectrums is unknown <\/span><b>(13:07)<\/b><span style=\"font-weight: 400;\">. However, recent survey studies of EDS mothers, mothers with autism, and control groups have revealed potential relationships between autism and EDS <\/span><b>(11:58)<\/b><span style=\"font-weight: 400;\">. Findings suggest that 1) hypermobility occurs on a spectrum <\/span><b>(11:58)<\/b><span style=\"font-weight: 400;\"> and 2) some hereditary relationship between EDS\/hEDS and autism exists. Response result trends across presented studies show individuals with EDS presenting slightly more symptoms than those with autism and significantly more than the control <\/span><b>(14:32; 16:21)<\/b><span style=\"font-weight: 400;\">. Two studies found differences by sex <\/span><b>(18:52)<\/b><span style=\"font-weight: 400;\"> &#8211; in one on autonomic symptoms, the difference by sex was present in all three groups <\/span><b>(30:15)<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: 400;\">The presenter notes a survey study that found EDS groups reported more adverse reactions to vaccination. She states that various subgroups are susceptible to different things and urges individuals with EDS to take vaccines slowly and for practitioners to judge on a case-by-case basis <\/span><b>(19:45)<\/b><span style=\"font-weight: 400;\">. Casanova outlines Mast Cell Activation Syndrome (MCAS) <\/span><b>(22:20)<\/b><span style=\"font-weight: 400;\"> and Postural Orthostatic Tachycardia Syndrome (POTS) <\/span><b>(31:25), <\/b><span style=\"font-weight: 400;\">which often co-occur with EDS, and presents hypotheses explaining this co-occurrence (<\/span><b>34:18)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: 400;\">Marfan Syndrome, Casanova explains, is another connective tissue disorder that deals with a mutation in the fibrin (storage areas\/binding sites) of proteins involved in connective tissues <\/span><b>(24:18)<\/b><span style=\"font-weight: 400;\">. When fibrin deficits or abnormalities are present, proteins and other rapidly moving molecules cannot bind properly <\/span><b>(25:15)<\/b><span style=\"font-weight: 400;\">. Researchers posit that collagen likely has similar storage\/binding characteristics to fibrin and other general connective tissue functions <\/span><b>(25:45)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h3><\/h3>\n<p><span style=\"font-weight: 400;\">Dr. Casanova highlights how much we do not know about collagen and connective tissue functions in general and wonders how many other ways collagen is involved in immune system regulation or as part of the actual functionality itself <\/span><b>(26:30)<\/b><span style=\"font-weight: 400;\">. She emphasizes that we have just realized connective tissue is not only structural but also intricately involved in development and body function <\/span><b>(44:35)<\/b><span style=\"font-weight: 400;\">. She outlines her new research partnership with Max Planck Institute <\/span><b>(45:12) <\/b><span style=\"font-weight: 400;\">before opening the floor to questions <\/span><b>(47:30)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p>&nbsp;<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_6 1_6 fusion-one-sixth fusion-column-last\" style=\"--awb-bg-size:cover;width:16.666666666667%;width:calc(16.666666666667% - ( ( 4% + 4% ) * 0.16666666666667 ) );\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div id=\"jump\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-padding-top:80px;--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-4\"><p>Certificates of participation are available after successful completion of a brief knowledge quiz at: <a href=\"https:\/\/www.classmarker.com\/online-test\/start\/?quiz=xmd5b97eac93d142\" target=\"_blank\" rel=\"noopener noreferrer\">HERE<\/a><\/p>\n<p>Handouts are online at: <a href=\"https:\/\/www.ariconference.com\/webinars\/EDS_2018.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">HERE<\/a><\/p>\n<\/div><div class=\"fusion-text fusion-text-5\"><p><strong>Published: 09\/12\/2018<\/strong><\/p>\n<p><img decoding=\"async\" class=\"lazyload alignleft size-full wp-image-3384\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/02\/Emily-Casanova-Ph.D.jpg\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/02\/Emily-Casanova-Ph.D.jpg\" alt=\"Emily Casanova, Ph.D\" width=\"98\" height=\"98\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%2798%27%20height%3D%2798%27%20viewBox%3D%270%200%2098%2098%27%3E%3Crect%20width%3D%2798%27%20height%3D%2798%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/02\/Emily-Casanova-Ph.D-66x66.jpg 66w, https:\/\/autism.org\/wp-content\/uploads\/2019\/02\/Emily-Casanova-Ph.D.jpg 98w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 98px) 100vw, 98px\" \/>Dr. Casanova earned her doctorate in Anatomy Science &amp; Neurobiology from the University of Louisville\u2019s Medical School. She is currently a Postdoctoral Fellow with the University of South Carolina\u2019s School of Medicine at Greenville, working in close conjunction with the Greenville Health System\u2019s (GHS) Departments of Psychology and Developmental-Behavioral Pediatrics in the Department of Pediatrics. She has research background in neurobiology, developmental biology, and some genetics, dermatology, and neuropathology, with particular foci on neurodevelopmental conditions such as autism and connective tissue disorders like Ehlers-Danlos Syndrome (EDS)\/Hypermobility Spectrum Disorders (HSD). Her current research foci\/topics of interest include: 1) functional classification of high-risk autism genes; 2) the characterization of genomic features common to autism risk genes and those genes\u2019 roles in the evolution of animal morphology; and 3) etiological overlap between autism and EDS\/HSD. In addition to her research interests in EDS\/HSD, she is also a zebra herself and is passionate about patient advocacy. She blogs at Science Over a Cuppa.<\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/div><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-3 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-background-color:#31478e;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1315.6px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_1_1 1_1 fusion-flex-column\" 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fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-recent-posts fusion-recent-posts-1 avada-container layout-default layout-columns-3\"><section class=\"fusion-columns columns fusion-columns-3 columns-3\"><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/research-updates-monogenic-syndromes\/\" aria-label=\"Research Updates: What Can Monogenic Syndromes Tell Us About the Underlying Causes of Autism?\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-700x441.jpg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Medical professional conducting a test or analysis\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271000%27%20height%3D%27667%27%20viewBox%3D%270%200%201000%20667%27%3E%3Crect%20width%3D%271000%27%20height%3D%27667%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-700x441.jpg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-320x202.jpg 320w, https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-700x441.jpg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-03-13T13:10:52-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/research-updates-monogenic-syndromes\/\">Research Updates: What Can Monogenic Syndromes Tell Us About the Underlying Causes of Autism?<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-03-13T13:10:52-05:00<\/span><span>May 27th, 2026<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/webinar\/assessment\/\" rel=\"category tag\">Assessment<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/genetics\/\" rel=\"category tag\">Genetics<\/a>, <a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/neurological\/\" rel=\"category tag\">Neurological<\/a>, <a href=\"https:\/\/autism.org\/category\/research\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/research-webinar\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>      Free webinar at 1:00 p.m. Eastern time (US), May 27, 2026 Dr. Daniel Vogt, Ph.D., will discuss his current research on monogenic syndromes and what they can tell us<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/gene-therapy-for-mutations-in-the-iqsec2-gene\/\" aria-label=\"Gene Therapy for Mutations in the IQSEC2 Gene\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-700x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Two puzzle pieces with the words &quot;Autism&quot; and &quot;Genetics&quot; on them\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271192%27%20height%3D%27924%27%20viewBox%3D%270%200%201192%20924%27%3E%3Crect%20width%3D%271192%27%20height%3D%27924%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-700x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-320x202.jpeg 320w, https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-700x441.jpeg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-03-18T18:21:41-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/gene-therapy-for-mutations-in-the-iqsec2-gene\/\">Gene Therapy for Mutations in the IQSEC2 Gene<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-03-18T18:21:41-05:00<\/span><span>March 17th, 2026<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/immune-issues\/\" rel=\"category tag\">Immune Issues<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/neurological\/\" rel=\"category tag\">Neurological<\/a>, <a href=\"https:\/\/autism.org\/category\/parenting\/\" rel=\"category tag\">Parenting<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/prenatal-health\/\" rel=\"category tag\">Pregnancy<\/a>, <a href=\"https:\/\/autism.org\/category\/research\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/research-webinar\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/wao\/\" rel=\"category tag\">WAO<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>     The IQSEC2 protein is a guanine nucleotide exchange factor for Arf6.\u00a0 Pathogenic variants in the X-linked IQSEC2 gene are associated with drug-resistant epilepsy, severe intellectual disability, and autism.\u00a0 The vast<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/using-machine-learning-for-biomarker-discovery\/\" aria-label=\"Towards the Development of a Diagnostic Test for Autism Spectrum Disorder: Data Science Meets Metabolomics\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/02\/AdobeStock_209628810-700x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Biomarkers DNA image\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271706%27%20viewBox%3D%270%200%202560%201706%27%3E%3Crect%20width%3D%272560%27%20height%3D%271706%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/02\/AdobeStock_209628810-700x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/02\/AdobeStock_209628810-320x202.jpeg 320w, https:\/\/autism.org\/wp-content\/uploads\/2024\/02\/AdobeStock_209628810-700x441.jpeg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-02-23T14:18:06-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/using-machine-learning-for-biomarker-discovery\/\">Towards the Development of a Diagnostic Test for Autism Spectrum Disorder: Data Science Meets Metabolomics<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-02-23T14:18:06-05:00<\/span><span>February 10th, 2026<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/biomarkers\/\" rel=\"category tag\">Biomarkers<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/genetics\/\" rel=\"category tag\">Genetics<\/a>, <a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/immune-issues\/\" rel=\"category tag\">Immune Issues<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/neurological\/\" rel=\"category tag\">Neurological<\/a>, <a href=\"https:\/\/autism.org\/category\/research\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/research-webinar\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>      Hear Juergen Hahn, Ph.D., ARI Scientific Advisory Board member, discuss how using machine learning can lead to biomarker discoveries in autism research. Handouts are online HERE   <\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/how-genetics-is-shaping-the-field-of-autism-research\/\" aria-label=\"How Genetics is Shaping the Field of Autism Research\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-700x441.jpg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Medical professional conducting a test or analysis\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271000%27%20height%3D%27667%27%20viewBox%3D%270%200%201000%20667%27%3E%3Crect%20width%3D%271000%27%20height%3D%27667%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-700x441.jpg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-320x202.jpg 320w, https:\/\/autism.org\/wp-content\/uploads\/2018\/12\/genes-4-700x441.jpg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-02-23T14:19:25-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/how-genetics-is-shaping-the-field-of-autism-research\/\">How Genetics is Shaping the Field of Autism Research<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-02-23T14:19:25-05:00<\/span><span>January 27th, 2026<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/webinar\/environmental-factors\/\" rel=\"category tag\">Environmental Factors<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/genetics\/\" rel=\"category tag\">Genetics<\/a>, <a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/neurological\/\" rel=\"category tag\">Neurological<\/a>, <a href=\"https:\/\/autism.org\/category\/research\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/research-webinar\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>      Learn about how research on genetic influences is shaping our understanding of autism.      About the speaker: M. Pilar Trelles, MD, is a licensed and<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/breakthroughs-in-understanding-roles-of-genes-and-environment-in-autism\/\" aria-label=\"Breakthroughs in Understanding roles of Genes and Environment in Autism\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/01\/paid_-dna-700x441.jpg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"autism genetic research, beyond genetics autism\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271600%27%20height%3D%271067%27%20viewBox%3D%270%200%201600%201067%27%3E%3Crect%20width%3D%271600%27%20height%3D%271067%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/01\/paid_-dna-700x441.jpg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/01\/paid_-dna-320x202.jpg 320w, https:\/\/autism.org\/wp-content\/uploads\/2019\/01\/paid_-dna-700x441.jpg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-01-05T18:58:39-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/breakthroughs-in-understanding-roles-of-genes-and-environment-in-autism\/\">Breakthroughs in Understanding roles of Genes and Environment in Autism<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2026-01-05T18:58:39-05:00<\/span><span>December 2nd, 2025<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/webinar\/environmental-factors\/\" rel=\"category tag\">Environmental Factors<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/genetics\/\" rel=\"category tag\">Genetics<\/a>, <a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/neurological\/\" rel=\"category tag\">Neurological<\/a>, <a href=\"https:\/\/autism.org\/category\/research\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/research-webinar\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>          About the speaker: Dr. Jonathan Sebat, Director, Beyster Center for Psychiatric Genomics Dr. Sebat leads an interdisciplinary team in the clinical and genomic analysis of<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/molecular-and-celluar-mechanisms\/\" aria-label=\"The Low-Hanging Fruit: Exploring Monogenic Syndromes with Elevated Rates of Autism\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-700x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Two puzzle pieces with the words &quot;Autism&quot; and &quot;Genetics&quot; on them\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271192%27%20height%3D%27924%27%20viewBox%3D%270%200%201192%20924%27%3E%3Crect%20width%3D%271192%27%20height%3D%27924%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-700x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-320x202.jpeg 320w, https:\/\/autism.org\/wp-content\/uploads\/2019\/06\/AdobeStock_845339561-700x441.jpeg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2024-08-07T10:37:37-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/molecular-and-celluar-mechanisms\/\">The Low-Hanging Fruit: Exploring Monogenic Syndromes with Elevated Rates of Autism<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2024-08-07T10:37:37-05:00<\/span><span>July 15th, 2024<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/autism-spectrum-disorders\/\" rel=\"category tag\">Autism Spectrum Disorders<\/a>, <a href=\"https:\/\/autism.org\/category\/biomarkers\/\" rel=\"category tag\">Biomarkers<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/genetics\/\" rel=\"category tag\">Genetics<\/a>, <a href=\"https:\/\/autism.org\/category\/news\/\" rel=\"category tag\">News<\/a>, <a href=\"https:\/\/autism.org\/category\/autism-spectrum-disorders\/ways-to-help\/\" rel=\"category tag\">Ways to Help<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>   Dr. Daniel Vogt, Ph.D., explores monogenic syndromes and what they can tell us about the underlying causes of autism. He describes signaling pathways critical in early development, highlighting the electrical nature of<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":7986,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[32,30,31,24],"tags":[4693,58,4705,4729,4728,6447,4730],"class_list":["post-11130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-assessment","category-genetics","category-immune-issues","category-webinar","tag-ari-webinar","tag-autism","tag-casanova","tag-eds","tag-ehlers-danlos-syndrome","tag-ehlers-danlos-syndrome-and-other-hypermobility-spectrum-disorders-in-families-with-autism","tag-hypermobility-spectrum-disorders"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ehlers-Danlos Syndrome and Other Hypermobility Spectrum Disorders in Families with Autism<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/autism.org\/ehlers-danlos-syndrome-and-other-hypermobility-spectrum-disorders-in-families-with-autism\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ehlers-Danlos Syndrome and Other Hypermobility Spectrum Disorders in Families with Autism\" \/>\n<meta property=\"og:url\" content=\"https:\/\/autism.org\/ehlers-danlos-syndrome-and-other-hypermobility-spectrum-disorders-in-families-with-autism\/\" \/>\n<meta property=\"og:site_name\" content=\"Autism Research Institute\" \/>\n<meta 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