{"id":17677,"date":"2024-06-20T16:04:11","date_gmt":"2024-06-20T21:04:11","guid":{"rendered":"https:\/\/autism.org\/?p=17677"},"modified":"2025-03-12T14:26:25","modified_gmt":"2025-03-12T19:26:25","slug":"blood-brain-barrier-dysfunction-in-pediatric-acute-neuropsychiatric-syndrome-pans-and-regulation","status":"publish","type":"post","link":"https:\/\/autism.org\/blood-brain-barrier-dysfunction-in-pediatric-acute-neuropsychiatric-syndrome-pans-and-regulation\/","title":{"rendered":"Research Update: Blood-brain barrier dysfunction in Pediatric Acute Neuropsychiatric Syndrome (PANS) and Regulation"},"content":{"rendered":"<p><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_6 1_6 fusion-one-sixth fusion-column-first\" style=\"--awb-padding-top:80px;--awb-bg-size:cover;width:13.3333%; margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-1 fusion_builder_column_2_3 2_3 fusion-two-third\" style=\"--awb-padding-top:80px;--awb-bg-size:cover;width:65.3333%; margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-1\" style=\"--awb-text-transform:none;\"><p><span style=\"font-weight: 400;\"><a href=\"#jump\">Dr. Jennifer Frankovich<\/a> reviews what we know about the underlying mechanisms, trajectories, and symptoms of Pediatric Acute Neuropsychiatric Syndrome (PANS). She discusses the role of the Basal Ganglia in PANS symptoms and cites contemporary research that highlights this connection. Frankovich touches on the disruption of the blood-brain barrier and auto-antibody regulation in PANS.\u00a0<\/span><\/p>\n<p><em>Playback of Dr. Mondal&#8217;s presentation and Dr. Hussein&#8217;s presentation will be available at a future date.<\/em><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-video fusion-youtube fusion-aligncenter\" style=\"--awb-max-width:600px;--awb-max-height:360px;--awb-width:100%;\"><div class=\"video-shortcode\"><div class=\"fluid-width-video-wrapper\" style=\"padding-top:60%;\" ><iframe title=\"YouTube video player 1\" src=\"https:\/\/www.youtube.com\/embed\/FCQRiy8pMC4?wmode=transparent&autoplay=0\" width=\"600\" height=\"360\" allowfullscreen allow=\"autoplay; fullscreen\"><\/iframe><\/div><\/div><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-text-transform:none;\"><h2>In this webinar:<\/h2>\n<p><strong>1:30<\/strong> &#8211; PANS\/PANDAS overview<br \/>\n<strong>3:10<\/strong> &#8211; Underlying mechanisms<br \/>\n<strong>5:00<\/strong> &#8211; Common symptoms<br \/>\n<strong>7:55<\/strong> &#8211; PANS trajectories<br \/>\n<strong>9:35<\/strong> &#8211; Basal Ganglia<br \/>\n<strong>13:12<\/strong> &#8211; Antibodies and the blood-brain barrier<\/p>\n<h2><b>PANS\/PANDAS<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Frankovich outlines Pediatric Acute Neuropsychiatric Syndrome (PANS) and Pediatric Acute Neuropsychiatric Disorders Associated with Strep (PANDAS), underscoring the different triggers attributed to both conditions <\/span><b>(1:30)<\/b><span style=\"font-weight: 400;\">. Classification criteria for both PANS and PANDAS include a sudden onset of obsessive-compulsive disorder or eating restrictions along with at least two other co-occurring conditions like anxiety, sensory dysregulation, motor abnormalities, developmental regression, and deterioration of cognitive functioning <\/span><b>(2:15)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2><b>Underlying mechanisms<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">Children with PANS-related symptoms often have some form of immune predisposition. The speaker explains that PANS occurs after a person gets an infection, which, due to predisposition, causes a systemic inflammatory response. She notes that these inflammatory responses may lead to Basal Ganglia inflammation, altered neuronal signaling, microbial activation, and more <\/span><b>(3:10)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2><b>Common symptoms<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The presenter describes classic PANS experiences, such as swelling in the knees, hips, and heel bones, back pain and inflammation, and evidence of psoriasis. She explains that children who experience their first case between the ages of five and ten will likely have arthritis by the time they are 14 <\/span><b>(5:00)<\/b><span style=\"font-weight: 400;\">. Frankovich highlights our bodies\u2019 abilities to self-regulate inflammation, noting that in many cases, PANS symptoms are resolved on their own <\/span><b>(7:15)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2><b>PANS Trajectories<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">There are generally four different trajectories for PANS:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relapsing and remitting &#8211; returning to the same baseline<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relapsing and remitting &#8211; worsening baseline across time<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Primary persistent &#8211; no return to baseline, remains in chronic episode<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Secondary persistent &#8211; multiple episodes with increasing baseline until it reaches a chronic episode.\u00a0<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Frankovich asserts that the primary and secondary persistent trajectories are likely more related to autoimmune predispositions than the others. Therefore, she continues, these trajectories require the most intense treatments and assessments <\/span><b>(7:55)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2><b>Basal Ganglia<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">The Basal Ganglia (BG), a group of nuclei located beneath the cerebral cortex, has an inhibitory influence on motor and behavior systems. The speaker notes that inflammation, autoantibodies, and injury can disrupt the BG, affecting movements, mood, emotion, behavior, procedural learning, and cognition <\/span><b>(9:35)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Frankovich briefly presents four brain imaging studies suggesting BG inflammation in PANS. She also discusses three studies indicating that patients experience abnormal movements during REM sleep cycles. These REM movements predict Parkinson&#8217;s in adults, making this a critical area of research and care <\/span><b>(10:25)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Other physical signs of BG disruption include specific tongue and mouth movements. For example, a positive glabellar tap reflex is present in children with PANS, though it should disappear after infancy. Other abnormal tongue movements, like milkmaid grip, are discussed <\/span><b>(11:55)<\/b><span style=\"font-weight: 400;\">. The speaker notes that between 80 and 92% of patients in her clinic exhibit at least one sign of BG disruption <\/span><b>(12:25)<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><span style=\"font-weight: 400;\">19% of autistic youth also have a positive glabellar tap, and 27% have milkmaid grip tongue movements. The presenter, therefore, asserts that these BG signs are not unique to PANS and should be investigated carefully across groups <\/span><b>(12:38)<\/b><span style=\"font-weight: 400;\">.\u00a0<\/span><\/p>\n<h2><b>Antibodies and the blood-brain barrier<\/b><\/h2>\n<p><span style=\"font-weight: 400;\">PANS autoantibodies target interneurons and have been found in healthy kids and children with PANDAS. Frankovich explains that if these antibodies are causing problems in the body, it is because they are crossing the blood-brain barrier (BBB) <\/span><b>(13:12)<\/b><span style=\"font-weight: 400;\">. She highlights that current research suggests local disruptions to the BBB are associated with PANS symptoms <\/span><b>(13:50)<\/b><span style=\"font-weight: 400;\">.<\/span><\/p>\n<p><em><strong>Originally published on June 14, 2024<\/strong><\/em><\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-2 fusion_builder_column_1_6 1_6 fusion-one-sixth fusion-column-last\" style=\"--awb-padding-top:80px;--awb-bg-size:cover;width:13.3333%;\"><div class=\"fusion-column-wrapper fusion-flex-column-wrapper-legacy\"><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:40px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><div id=\"#jump\" class=\"fusion-container-anchor\"><div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-2 has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-3 fusion_builder_column_1_3 1_3 fusion-one-third fusion-column-first\" style=\"--awb-bg-size:cover;width:33.333333333333%;width:calc(33.333333333333% - ( ( 4% ) * 0.33333333333333 ) );margin-right: 4%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-3\" style=\"--awb-text-transform:none;\"><p><strong>The speakers:<\/strong><\/p>\n<p><strong>Jennifer Frankovich:\u00a0<\/strong><\/p>\n<div class=\"bio content-section\">\n<p><img decoding=\"async\" class=\"lazyload  wp-image-13656 alignleft\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27114%27%20height%3D%27111%27%20viewBox%3D%270%200%20114%20111%27%3E%3Crect%20width%3D%27114%27%20height%3D%27111%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2021\/09\/frankovich.jpg\" alt=\"\" width=\"114\" height=\"111\" \/>Dr. Frankovich is a Clinical Professor in the Department of Pediatrics, Division of Allergy, Immunology Rheumatology (AIR) at Stanford University\/Lucile Packard Children\u2019s Hospital (LPCH). Her clinical expertise is in systemic inflammatory and autoimmune diseases that co-occur with psychiatric symptoms. She completed her training in pediatrics, pediatric rheumatology, and clinical epidemiology at Stanford University\/LPCH. She directs the Stanford Immune-Behavioral Health Program (2012- present) where she and her psychiatry\/psychology collaborators have created a longitudinal clinical database and biorepository of patient and healthy control biospecimens. In addition to generating clinical data to better understand immune-behavioral health conditions, she is collaborating with basic science labs who aim to understand the immunological underpinnings of post-infectious neuropsychiatric conditions including PANS and related conditions.<\/p>\n<\/div>\n<p><strong>Publishing soon:<\/strong><\/p>\n<p class=\"elementtoproof\"><span style=\"font-size: 12.0pt; color: black; background: white;\"><img decoding=\"async\" class=\"lazyload wp-image-17679 alignleft\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/noor-hussein_profilephoto-e1705946649999.jpg\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/noor-hussein_profilephoto-e1705946649999.jpg\" alt=\"\" width=\"109\" height=\"124\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27109%27%20height%3D%27124%27%20viewBox%3D%270%200%20109%20124%27%3E%3Crect%20width%3D%27109%27%20height%3D%27124%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/noor-hussein_profilephoto-e1705946649999-200x228.jpg 200w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/noor-hussein_profilephoto-e1705946649999.jpg 244w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 109px) 100vw, 109px\" \/><\/span><\/p>\n<p class=\"elementtoproof\"><strong>Noor A. Hussein, PhD<\/strong> is a pharmacology scientist.<br \/>\n&#8220;My experience as a researcher has taught me to seek out new perspectives for exploration and discovery. As a dedicated biological and pharmacological researcher with over 7 years of experience with models of diseases such as cancer both in vitro and in vivo. During my masters and Ph.D. studies, I mastered lots of molecular biology techniques, including cell culture, cytotoxicity assays, western blot, quantitative PCR, immunofluorescence, flow cytometry. I utilized my skills to design experiments finding solutions to common problems in the biomedical field, especially cancer experimental and molecular therapeutics.&#8221;<\/p>\n<p class=\"elementtoproof\"><span style=\"font-size: 12.0pt; color: black; background: white;\"><img decoding=\"async\" class=\"lazyload wp-image-17678 alignleft\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small.jpg\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small.jpg\" alt=\"\" width=\"94\" height=\"118\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%2794%27%20height%3D%27118%27%20viewBox%3D%270%200%2094%20118%27%3E%3Crect%20width%3D%2794%27%20height%3D%27118%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-200x250.jpg 200w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-240x300.jpg 240w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-400x501.jpg 400w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-600x751.jpg 600w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-768x961.jpg 768w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-800x1001.jpg 800w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-818x1024.jpg 818w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-1200x1502.jpg 1200w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-1227x1536.jpg 1227w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small-1637x2048.jpg 1637w, https:\/\/autism.org\/wp-content\/uploads\/2024\/01\/mondal-small.jpg 1699w\" data-sizes=\"auto\" data-orig-sizes=\"(max-width: 94px) 100vw, 94px\" \/><\/span><\/p>\n<p><strong>Ayan Mondal, Ph.D. <\/strong>is a third-year post-doctoral research fellow in Prof Elizabeth Mellins&#8217; laboratory at Dept of pediatrics, Stanford University. &#8220;I completed my graduation from University of Calcutta, India, in 2017. I have conducted 1.5 years of research on molecular medicine following graduation and joined as a post-doctoral researcher at the Arnold School of Public health, University of South Carolina, in the year 2019. During the training, I studied neuroimmune signaling mechanisms in the gut-liver-brain axes in mouse models of metabolic disorders and military-deployment-associated disorders. My studies elucidated the mechanism of neuroinflammation and blood-brain barrier (BBB) dysfunction mediated by specific proteins that are elevated in blood during these disease conditions. In my post-doctoral research with Prof Mellins, I am studying changes in BBB function in PANS. I am focusing on elucidating the mechanisms of action of novel modulators of BBB that are relevant to homeostatic maintenance of the BBB and other novel modulators that increase BBB permeability during flares of PANS. My proposed experimental strategies include transcriptomic and proteomic approaches in cell types of the CNS neurovascular unit.&#8221;<\/p>\n<p class=\"elementtoproof\"><span style=\"font-size: 12.0pt; color: black; background: white;\">\u00a0<\/span><\/p>\n<\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-4 fusion_builder_column_2_3 2_3 fusion-two-third fusion-column-last\" style=\"--awb-bg-size:cover;width:66.666666666667%;width:calc(66.666666666667% - ( ( 4% ) * 0.66666666666667 ) );\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-4\"><h4>Take the knowledge quiz<\/h4>\n<p>Can&#8217;t see the quiz below? 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class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-top:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-recent-posts fusion-recent-posts-1 avada-container layout-default layout-columns-3\"><section class=\"fusion-columns columns fusion-columns-3 columns-3\"><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/gi-behavior\/\" aria-label=\"Research Updates: GI Symptoms &#038; Behavior\" class=\"hover-type-none\"><img decoding=\"async\" width=\"450\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/03\/GI2-450x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Child holding their stomach, showing signs of gut distress\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%27450%27%20height%3D%27450%27%20viewBox%3D%270%200%20450%20450%27%3E%3Crect%20width%3D%27450%27%20height%3D%27450%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/03\/GI2-450x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2024\/03\/GI2-66x66.jpeg 66w, https:\/\/autism.org\/wp-content\/uploads\/2024\/03\/GI2-450x441.jpeg 450w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-08-25T11:42:07-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/gi-behavior\/\">Research Updates: GI Symptoms &#038; Behavior<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-08-25T11:42:07-05:00<\/span><span>March 5th, 2025<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/anxiety-2\/\" rel=\"category tag\">Anxiety<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/gastrointestinal-webinar\/\" rel=\"category tag\">Gastrointestinal<\/a>, <a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/meltdowns\/\" rel=\"category tag\">Meltdowns<\/a>, <a href=\"https:\/\/autism.org\/category\/news\/\" rel=\"category tag\">News<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/nutrition\/\" rel=\"category tag\">Nutrition<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/research-webinar\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/self-care\/\" rel=\"category tag\">Self Care<\/a>, <a href=\"https:\/\/autism.org\/category\/self-injury-2\/\" rel=\"category tag\">Self Injury<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/self-injury\/\" rel=\"category tag\">Self-Injury<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/sensory\/\" rel=\"category tag\">Sensory<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>    Dr. Bradley Ferguson, PhD, a 2024 research grant recipient, discusses emerging research on the interaction of GI symptoms and stress in autism. He outlines recent investigations highlighting the connection between GI<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/blood-brain-barrier-dysfunction-in-pediatric-acute-neuropsychiatric-syndrome-pans-and-regulation\/\" aria-label=\"Research Update: Blood-brain barrier dysfunction in Pediatric Acute Neuropsychiatric Syndrome (PANS) and Regulation\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2020\/02\/anxiety-2-700x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Sad little child is hugging his mother\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%272099%27%20viewBox%3D%270%200%202560%202099%27%3E%3Crect%20width%3D%272560%27%20height%3D%272099%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2020\/02\/anxiety-2-700x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2020\/02\/anxiety-2-320x202.jpeg 320w, https:\/\/autism.org\/wp-content\/uploads\/2020\/02\/anxiety-2-700x441.jpeg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-03-12T14:26:25-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/blood-brain-barrier-dysfunction-in-pediatric-acute-neuropsychiatric-syndrome-pans-and-regulation\/\">Research Update: Blood-brain barrier dysfunction in Pediatric Acute Neuropsychiatric Syndrome (PANS) and Regulation<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-03-12T14:26:25-05:00<\/span><span>June 20th, 2024<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/webinar\/anxiety\/\" rel=\"category tag\">Anxiety<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/assessment\/\" rel=\"category tag\">Assessment<\/a>, <a href=\"https:\/\/autism.org\/category\/autism-spectrum-disorders\/\" rel=\"category tag\">Autism Spectrum Disorders<\/a>, <a href=\"https:\/\/autism.org\/category\/biomarkers\/\" rel=\"category tag\">Biomarkers<\/a>, <a href=\"https:\/\/autism.org\/category\/early-intervention\/\" rel=\"category tag\">Early Intervention<\/a>, <a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/medical-care\/\" rel=\"category tag\">Medical Care<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/neurological\/\" rel=\"category tag\">Neurological<\/a>, <a href=\"https:\/\/autism.org\/category\/news\/\" rel=\"category tag\">News<\/a>, <a href=\"https:\/\/autism.org\/category\/pans-pandas\/\" rel=\"category tag\">PANS\/PANDAS<\/a>, <a href=\"https:\/\/autism.org\/category\/parenting\/\" rel=\"category tag\">Parenting<\/a>, <a href=\"https:\/\/autism.org\/category\/research\/\" rel=\"category tag\">Research<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/school-issues\/\" rel=\"category tag\">School Issues<\/a>, <a href=\"https:\/\/autism.org\/category\/autism-spectrum-disorders\/ways-to-help\/\" rel=\"category tag\">Ways to Help<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>    Dr. Jennifer Frankovich reviews what we know about the underlying mechanisms, trajectories, and symptoms of Pediatric Acute Neuropsychiatric Syndrome (PANS). She discusses the role of the Basal Ganglia in PANS symptoms<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/pans-pandas-in-children-with-autism\/\" aria-label=\"PANS\/PANDAS in Children with Autism\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2020\/08\/AdobeStock_252792863-700x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Boy has strep throat. Children&#039;s ENT doctor examines boy&#039;s throat. Children&#039;s diseases, medical examination.\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271707%27%20viewBox%3D%270%200%202560%201707%27%3E%3Crect%20width%3D%272560%27%20height%3D%271707%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2020\/08\/AdobeStock_252792863-700x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2020\/08\/AdobeStock_252792863-320x202.jpeg 320w, https:\/\/autism.org\/wp-content\/uploads\/2020\/08\/AdobeStock_252792863-700x441.jpeg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/nicoleautism-com\/\" title=\"Posts by Nicole\" rel=\"author\">Nicole<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2022-05-10T16:48:41-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/pans-pandas-in-children-with-autism\/\">PANS\/PANDAS in Children with Autism<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/nicoleautism-com\/\" title=\"Posts by Nicole\" rel=\"author\">Nicole<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2022-05-10T16:48:41-05:00<\/span><span>August 26th, 2020<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/news\/\" rel=\"category tag\">News<\/a>, <a href=\"https:\/\/autism.org\/category\/pans-pandas\/\" rel=\"category tag\">PANS\/PANDAS<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>   The information below is from the 2019 ARI webinar, PANS\/PANDAS - Research Updates In rare cases, some children may experience the sudden onset of Obsessive-Compulsive Disorder or eating disorders. This pediatric acute-onset<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/pans-pandas-research-updates\/\" aria-label=\"PANS\/PANDAS &#8211; Research Updates\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/11\/Untitled-design-2019-10-16T121213.962-700x441.jpg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Doctor talking to a child during a check-up\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271280%27%20height%3D%27720%27%20viewBox%3D%270%200%201280%20720%27%3E%3Crect%20width%3D%271280%27%20height%3D%27720%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/11\/Untitled-design-2019-10-16T121213.962-700x441.jpg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2019\/11\/Untitled-design-2019-10-16T121213.962-320x202.jpg 320w, https:\/\/autism.org\/wp-content\/uploads\/2019\/11\/Untitled-design-2019-10-16T121213.962-700x441.jpg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-03-21T20:08:30-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/pans-pandas-research-updates\/\">PANS\/PANDAS  &#8211; Research Updates<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/autismadmin\/\" title=\"Posts by autismAdmin\" rel=\"author\">autismAdmin<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2025-03-21T20:08:30-05:00<\/span><span>November 5th, 2019<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/webinar\/anxiety\/\" rel=\"category tag\">Anxiety<\/a>, <a href=\"https:\/\/autism.org\/category\/autism-spectrum-disorders\/\" rel=\"category tag\">Autism Spectrum Disorders<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/immune-issues\/\" rel=\"category tag\">Immune Issues<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>    Susan Swedo, M.D. discusses research findings on causes, symptoms, and treatments for PANS\/PANDAS. She highlights the differences in syndromes and diseases and discusses the diagnosis and clinical presentation of PANS\/PANDAS, asserting<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/pans-pandas\/\" aria-label=\"PANS\/PANDAS\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/09\/AdobeStock_79181375-700x441.jpeg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Lonely child with a sad expression in the yard\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%272560%27%20height%3D%271707%27%20viewBox%3D%270%200%202560%201707%27%3E%3Crect%20width%3D%272560%27%20height%3D%271707%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/09\/AdobeStock_79181375-700x441.jpeg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2018\/09\/AdobeStock_79181375-320x202.jpeg 320w, https:\/\/autism.org\/wp-content\/uploads\/2018\/09\/AdobeStock_79181375-700x441.jpeg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/firespringint\/\" title=\"Posts by firespringInt\" rel=\"author\">firespringInt<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2019-12-11T04:48:04-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/pans-pandas\/\">PANS\/PANDAS<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/firespringint\/\" title=\"Posts by firespringInt\" rel=\"author\">firespringInt<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2019-12-11T04:48:04-05:00<\/span><span>September 7th, 2018<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/health\/\" rel=\"category tag\">Health<\/a>, <a href=\"https:\/\/autism.org\/category\/webinar\/immune-issues\/\" rel=\"category tag\">Immune Issues<\/a>, <a href=\"https:\/\/autism.org\/category\/parenting\/\" rel=\"category tag\">Parenting<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>   Free certificates of attendance are available upon successful completion of a brief knowledge quiz at: https:\/\/www.classmarker.com\/online-te\u2026 Watch Dr. Sue Swedo\u2019s presentation on the subset of individuals experiencing Obsessive\/Compulsive Disorder symptoms and are<\/p><\/div><\/article><article class=\"post fusion-column column col col-lg-4 col-md-4 col-sm-4\"><div class=\"fusion-flexslider fusion-flexslider-loading flexslider flexslider-hover-type-none\"><ul class=\"slides\"><li><a href=\"https:\/\/autism.org\/addressing-symptoms-of-pans-and-pots-nutritionally\/\" aria-label=\"Addressing Symptoms of PANS and POTS Nutritionally\" class=\"hover-type-none\"><img decoding=\"async\" width=\"700\" height=\"441\" src=\"https:\/\/autism.org\/wp-content\/uploads\/2017\/11\/Untitled-design-49-700x441.jpg\" class=\"attachment-recent-posts size-recent-posts lazyload\" alt=\"Fruits and vegetables\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%27http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%27%20width%3D%271280%27%20height%3D%27720%27%20viewBox%3D%270%200%201280%20720%27%3E%3Crect%20width%3D%271280%27%20height%3D%27720%27%20fill-opacity%3D%220%22%2F%3E%3C%2Fsvg%3E\" data-orig-src=\"https:\/\/autism.org\/wp-content\/uploads\/2017\/11\/Untitled-design-49-700x441.jpg\" data-srcset=\"https:\/\/autism.org\/wp-content\/uploads\/2017\/11\/Untitled-design-49-320x202.jpg 320w, https:\/\/autism.org\/wp-content\/uploads\/2017\/11\/Untitled-design-49-700x441.jpg 700w\" data-sizes=\"auto\" \/><\/a><\/li><\/ul><\/div><div class=\"recent-posts-content\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2022-02-03T09:41:41-05:00<\/span><h4 class=\"entry-title\"><a href=\"https:\/\/autism.org\/addressing-symptoms-of-pans-and-pots-nutritionally\/\">Addressing Symptoms of PANS and POTS Nutritionally<\/a><\/h4><p class=\"meta\"><span class=\"vcard\" style=\"display: none;\"><span class=\"fn\"><a href=\"https:\/\/autism.org\/author\/melanie\/\" title=\"Posts by Melanie Glock\" rel=\"author\">Melanie Glock<\/a><\/span><\/span><span class=\"updated\" style=\"display:none;\">2022-02-03T09:41:41-05:00<\/span><span>November 15th, 2017<\/span><span class=\"fusion-inline-sep\">|<\/span><a href=\"https:\/\/autism.org\/category\/webinar\/nutrition\/\" rel=\"category tag\">Nutrition<\/a>, <a href=\"https:\/\/autism.org\/webinars\/\" rel=\"category tag\">Webinar<\/a><span class=\"fusion-inline-sep\">|<\/span><\/p><p>          Vicki Kobliner MS RDN is a Registered Dietitian\/Nutritionist with years of expertise in applying a functional approach to nutrition. She develops individualized plans for clients<\/p><\/div><\/article><\/section><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":9932,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[3781,32,21,9735,9698,26,9651,3782,20,9450,37,19,38,9475,24],"tags":[5787,4921,3929,6829],"class_list":["post-17677","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anxiety","category-assessment","category-autism-spectrum-disorders","category-biomarkers","category-early-intervention","category-health","category-medical-care","category-neurological","category-news","category-pans-pandas","category-parenting","category-research","category-school-issues","category-ways-to-help","category-webinar","tag-addressing-symptoms-of-pans-and-pots-nutritionally","tag-autism-symptoms","tag-pans","tag-pans-pandas-suedo-2018","webinar-author-frankovich-hussein-mondal"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v26.6 (Yoast SEO v27.1.1) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Research Update: Blood-brain barrier dysfunction in Pediatric Acute Neuropsychiatric Syndrome (PANS) and Regulation - Autism Research Institute<\/title>\n<meta name=\"description\" content=\"Tune in to hear research updates from Noor A. Hussein, PhD and Ayan Mondal, PhD on Pediatric Acute Neuropsychiatric Syndrome.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/autism.org\/blood-brain-barrier-dysfunction-in-pediatric-acute-neuropsychiatric-syndrome-pans-and-regulation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research Update: Blood-brain barrier dysfunction in Pediatric Acute Neuropsychiatric Syndrome (PANS) and Regulation\" \/>\n<meta property=\"og:description\" content=\"Tune in to hear research updates from Noor A. 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